Scientist II, Analytical Chemistry


About Debut

Debut is the unconventional innovation lab spearheading the next generation of big business. Only Debut has a scalable, integrated, climate-positive creation model powered by biotechnology that puts human wellbeing at the center of everything we do—setting the new standard for profitable business and a new pace for an ever-changing world.  Our hybrid biotechnology approaches unlock latent markets, providing access to sustainably produced, natural ingredients with health benefits that cannot be obtained through other methods. We are committed to traversing the entire process, from ingredient discovery to the scaling of these products, for consumer markets. If you are passionate, enjoy fast-paced innovation and collaborative teams, then Debut is for you.  


We are seeking a highly skilled Analytical Chemist with expertise in rapid development of analytical assays for fermentation-derived small molecules. The ideal candidate will possess a strong background in analytical method development and application thereof to different phases of a project where throughput, precision, accuracy, and cost of analysis will need to be optimized. Experience with Design of Experiments (DOE) and JMP software is highly desired, while familiarity with Python and Benchling would be advantageous.   

Essential Functions 

  • Develop and validate analytical assays for the characterization of fermentation-derived small molecules. 
  • Rapidly develop assays for small molecules in early proof of concept work, while keeping an eye on maturing the methods for either high throughput screening or for high precision, high accuracy analysis. 
  • Validate analytical methods according to regulatory guidelines and industry standards. 
  • Transfer validated methods to third-party CMOs, ensuring seamless integration into their processes. 
  • Utilize Design of Experiments (DOE) methodologies to optimize assay parameters and improve assay precision and accuracy. 
  • Analyze and interpret experimental data using statistical tools such as JMP. 
  • Collaborate with cross-functional teams including Research & Development, Manufacturing, and Quality Control to support product development and process optimization. 
  • Maintain accurate documentation of experimental procedures, results, and observations. 

Education and Experience 

  • PhD with 2 years of experience OR MS with 8 years experience, OR BS with 10 years experience in Analytical Chemistry, Biochemistry, or related field.   
  • Minimum of 2 years of experience in developing and validating analytical assays for fermentation-derived small molecules. 
  • Proven track record of successfully developing and validating analytical methods. 
  • Experience with Design of Experiments (DOE) and proficiency in JMP software desired. 
  • Familiarity with programming languages such as Python is desirable. 
  • Experience with Benchling or similar LIMS systems a plus. 
  • Experience with Liquid Chromatography coupled with Ultraviolet Detection (LC-UV) is required. 
  • Familiarity with other Liquid Chromatography hyphenated techniques such as LC-RI (Refractive Index) and LC-MS (Mass Spectrometry) is desired. 
  • Experience with Gas Chromatography coupled with Flame Ionization Detection (GC-FID) and Gas Chromatography-Mass Spectrometry (GC-MS). 
  • Excellent communication skills and ability to work effectively in a collaborative team environment. 
  • Strong organizational skills with the ability to prioritize tasks and manage multiple projects simultaneously. 


Essential Physical Characteristics 

The physical characteristics described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable qualified individuals with disabilities to perform the essential functions of a job, on a case-by-case basis. 

  • Continuous upward and downward flexion of the neck.  
  • Frequent: sitting, repetitive use of hands to operate computers, printers and copiers.  
  • Frequently uses hands to feel objects or control tools (e.g. pipetting).  Laboratory operations require dexterity and care to perform studies as required. 
  • Occasional: walking, standing, climbing stairs, bending and twisting of neck, bending and twisting of waist, squatting, simple grasping, reaching above and below shoulder level, and occasional lifting and carrying of files or material weighing up to 50 pounds. 
  • Must be willing to work with biohazardous agents (up to BSL2) and chemicals. 
  • The R&D laboratory will result in exposure to hot and cold temperatures, noise, fumes, limited dust, and oily coolants. 
  • The performance of this position will present exposure to an industrial environment and requires support and compliance with the published Company PPE policy including but not limited to the use of personal protective equipment such as safety glasses with side shields, appropriate attire, safety shoes, hard hat, hearing protection, etc. 


Condition of Employment 

As part of Debut’s pre-employment process, prospective candidates will undergo a background check prior to beginning employment. Additional types of background investigations may be conducted based on the job-related activities of the position. 

Debut is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status. 


Salary: $100,000 - $130,000 


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